Binding Properties in Vitro of Antacids for Conjugated Bile Acids
نویسندگان
چکیده
منابع مشابه
Chemical properties of bile acids. IV. Acidity constants of glycine-conjugated bile acids.
The dissociation constants for the carboxyl group of a series of glycine (N-acyl)-conjugated and unconjugated bile acids were determined by potentiometric titration using dimethylsulfoxide-water and methanol-water mixtures of varying proportions. The pKa values in water were calculated by extrapolating the experimental values determined in different mole fractions of the organic solvent mixture...
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A method has been developed and validated for the determination of the six major conjugated bile acids, cholesterol, and total phospholipids in bile of human subjects previously injected with 4-(14)C-cholesterol. The procedure is designed for use with 5-10 ml of duodenal or T-tube bile and eliminates difficulties associated with existing methods for bile acid determination, in particular the re...
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In 1916 Wieland and Sorge (1) first described the formation of addition compounds of desoxycholic acid with fatty acids, and suggested the possible importance of this “choleic acid principle” in furthering the absorption of fatty acids and other substances from the intestinal canal. In human bile, however, desoxycholic acid is united with glycine and taurine; hence it is of considerable importa...
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In this study, we compared in vitro calcium binding by the taurine and glycine conjugates of the major bile acids in human bile: cholic (CA), chenodeoxycholic (CDCA) and deoxycholic (DCA) acids, together with the cholelitholytic bile acids unodeoxycholic (UDCA) and unocholic (UCA) acids. At physiological total calcium ( C a m ) (1-15 mM) and bile acid (BA) (10-50 mM) concentrations, all the bil...
متن کاملA method for the separation of glycine-conjugated bile acids as a group from taurine-conjugated bile acids.
Ileal disease, liver disease, and other pathologic conditions have been shown to affect the glycine:taurine ratio (1). The procedure used for determining the glycine:taurine ratio is to separate the individual conjugated bile acids on thin-layer chromatograms and estimate the quantities of each bile acid to get the ratio (2, 3). Sometimes two or more solvent systems are needed to separate the i...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1977
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)32140-7